It's possible that there will be a vaccine for Dengue Fever, a mosquito-borne disease that has a mortality rate of 1-5%. Prior to 1981, there were no cases of Dengue Fever in the western hemisphere. That has changed; incidents include an outbreak in Brownsville TX in 2005.
The vaccine will be "live" attenuated, which will increase resistance to taking it. And even if many end up taking it, we'll end up with the free rider problem! But still, anything is better than nothing.
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